• Neurohistologist

    Job Locations US-CA-San Diego
    Posted Date 2 months ago(2/27/2019 6:03 PM)
    Job ID
    # of Openings
    Research and Development
  • Overview

    Ready to join a team committed to moving gene therapies into the clinical and commercial settings for patients and families devastated by rare neurological genetic diseases? AveXis is advancing cutting-edge science to treat rare and life-threatening genetic diseases starting with our clinical-stage, proprietary gene therapy candidate, AVXS-101 (ZOLGENSMA®). We are in the midst of an incredible journey and are looking for passionate individuals to join us on this important mission.


    AveXis, Inc., a Novartis Company, is a clinical-stage gene therapy company, dedicated to developing and commercializing novel treatments for patients suffering from rare and life-threatening neurological genetic diseases. Our initial product candidate, AVXS-101, is our proprietary gene therapy product candidate currently in development for the treatment of spinal muscular atrophy, or SMA, Type 1, the leading genetic cause of infant mortality, and for the treatment of SMA Type 2. The U.S. Food and Drug Administration, or FDA, has granted AVXS-101 Orphan Drug Designation for the treatment of all types of SMA and Breakthrough Therapy Designation, as well as Fast Track Designation for the treatment of SMA Type 1. In addition to developing AVXS-101 to treat SMA Type 1 and Type 2, we also plan to develop other novel treatments for rare neurological diseases, including Rett syndrome (RTT) and a genetic form of amyotrophic lateral sclerosis (ALS) caused by mutations in the superoxide dismutase 1 (SOD1) gene.


    AveXis is seeking a skilled Neurohistologist to process tissues for immunohistochemistry and immunofluorescence. This individual will function as a technical resource, performing all aspects of histology including tissue collection, processing and immunostaining with limited supervision.


    • Animal necropsy and/or perfusion.
    • Processing, cutting, and mounting tissue specimens (large and small animal) onto glass slides.
    • Analyze results and generate reports on assays performed.
    • Serve as technical resource, training and supervising other scientists in histology and equipment usage.
    • Manage equipment maintenance and calibration.
    • Manage multiple project coordination.


    • Bachelor’s degree in Biology or related scientific discipline required.
    • 1-2 years of experience processing tissues for immunohistochemistry and immunofluorescence.
    • Experience with floating and mounted rodent sections required. Large animal experience is preferred. 
    • Demonstrated proficiency in histology and complex tissue analysis.
    • Experience with histological examination of neuronal tissues, whole brain slices, and brain substructure evaluation.
    • Light and confocal microscopy experience preferred.


    The level of this position will be based on the final candidate’s qualifications.


    Please note this job description is not designed to cover or contain a comprehensive listing of activities, duties or responsibilities that are required of the employee for this job. Duties, responsibilities and activities may change at any time with or without notice. 


    AveXis is committed to creating a diverse environment and is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, gender, gender identity, national origin, genetics, disability, age, sexual orientation or veteran status.



    Sorry the Share function is not working properly at this moment. Please refresh the page and try again later.
    Share on your newsfeed