• Senior Scientist - Research & Development

    Job Locations US-CA-San Diego
    Posted Date 1 month ago(3/22/2018 11:15 AM)
    Job ID
    # of Openings
    R & D
  • Overview

    Ready to join a team committed to moving gene therapies into the clinical setting for patients and families devastated by rare neurological genetic diseases?  AveXis is advancing cutting-edge science to treat rare and life-threatening genetic diseases starting with our clinical-stage, proprietary gene therapy candidate, AVXS-101.  We are at the beginning of an incredible journey, and are looking for passionate individuals to join us on this important mission.


    Position Summary

    AveXis, Inc. is a clinical-stage gene therapy company, dedicated to developing and commercializing novel treatments for patients suffering from rare and life-threatening neurological genetic diseases. Our initial product candidate, AVXS-101, is our proprietary gene therapy product candidate currently in development for the treatment of spinal muscular atrophy, or SMA, Type 1, the leading genetic cause of infant mortality, and for the treatment of SMA Type 2. The U.S. Food and Drug Administration, or FDA, has granted AVXS-101 Orphan Drug Designation for the treatment of all types of SMA and Breakthrough Therapy Designation, as well as Fast Track Designation for the treatment of SMA Type 1. In addition to developing AVXS-101 to treat SMA Type 1 and Type 2, we also plan to develop other novel treatments for rare neurological diseases, including Rett syndrome (RTT) and a genetic form of amyotrophic lateral sclerosis (ALS) caused by mutations in the superoxide dismutase 1 (SOD1) gene.

    The Senior Scientist, Research and Development role will be located in our San Diego offices and is responsible for executing in vitro experiments for AveXis programs. This individual will work in the laboratory, responsible for execution of experiments related to existing and pipeline products. This individual will work with scientists in the Research and Development department, as well as report to the Vice President of Research and Development.


    • Cell culture experiments supporting existing and pipeline programs
    • Protein engineering, cloning, protein expression, purification
    • Mammalian expression systems to support protein expression studies
    • Transient transfection in cell culture systems
    • Design of experiments to identify and optimize key parameters for protein expression


    • PhD degree in Biology, cell biology, pharmaceutical sciences, or related field
    • Laboratory experience in a molecular and cell biology laboratory
      • Publications and/or demonstrable experience desired
    • Specific laboratory experience desired includes, but is not limited to:
      • Culture of mammalian cells in cell culture
      • Molecular biology including cloning and ddPCR
      • Protein expression
      • Production of recombinant virus
    • Up to 25% travel may be required.

    Please note this job description is not designed to cover or contain a comprehensive listing of activities, duties or responsibilities that are required of the employee for this job. Duties, responsibilities and activities may change at any time with or without notice. 


    AveXis is committed to creating a diverse environment and is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, gender, gender identity, national origin, genetics, disability, age, sexual orientation or veteran status.



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